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Better efficacy of methotrexate given by intramuscular injection than orally in patients with rheumatoid arthritis
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Aligned with lessons from hematologic malignancies and tailored to GBM-specific hurdles, current BsAb efforts in GBM coalesce around three translational thrusts: (1) adapting T-cell redirection via CD3- or CD16-engaging BsAbs against GBM-relevant antigens such as epidermal growth factor receptor vIII (EGFRvIII), interleukin-13 receptor subunit alpha-2 (IL-13Rα2), and human epidermal growth factor receptor 2 (HER2) [35]
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