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Preclinical rodent models of peripheral neuropathy have examined sensory signaling parameters following ARA-290 administration, documenting that ARA-290 produces long-term relief of neuropathic pain in a rat spared-nerve-injury model, coupled with suppression of the spinal microglial neuroinflammatory response, suggestive of a mechanistic link between the two [2], making ARA-290 a reference compound in tissue-protection and neuroimmunology research examining innate-repair-receptor-mediated cytoprotective and anti-inflammatory signaling in preclinical models

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doi: 10.3389/fendo.2020.00033