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Injection-Based Administration Subcutaneous injections: All GLP-1 RAs are administered via subcutaneous injection Prefilled pens: Most common delivery system, allows for self-administration Auto-injectors: Simplify the process for patients with dexterity issues Multi-dose pens: Require dose dialing and needle attachment Dosing frequency: Daily: Liraglutide (Saxenda®, Victoza®), some formulations of exenatide (Byetta®) Weekly: Semaglutide (Wegovy®, Ozempic®), tirzepatide (Mounjaro®, Zepbound®), dulaglutide (Trulicity®), exenatide extended-release (Bydureon®) Titration schedules: Most FDA-approved GLP-1 RAs require gradual dose escalation to minimize gastrointestinal side effects
