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Repeated oral gavage using low doses of CTB-FVIII-HC/LC into HA mice resulted in ~10-fold decrease in both neutralizing and binding ADA titers, which was comparable to the tolerance observed with tobacco cells co-expressing CTB-FVIII-HC and C2 domains (8-fold) [51, 52]
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Acknowledgements MA thanks the Indian Council of Medical Research for financial support (Grant No
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