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Mitochondriën
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Reductions in the levels of IRSs and insulin-induced IRSs and a decrease in insulin receptor β phosphorylation were observed upon exposure to HNE at non-toxic concentrations (Demozay et al., Conclusions The adducts of reactive aldehydes with membrane proteins participate in physiological, as well as pathological processes and can determine variable functional consequences, in relation with the protein targets of adduction and their functional roles
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