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MOTS-c, as a small molecular active peptide, has been reported to have potential applications in aging, insulin resistance, cardiovascular disease and inflammation ( Figure 1 )
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Dynamic data was first fit into kinetic models with T 1 as an unknown parameter to estimate apparent in vivo T 1 of VitC, which was subsequently incorporated into the kinetic model as a fixed parameter to generate k assuming T 1 is the same across the subjects
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