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Phase 2 Obesity Trial — New England Journal of Medicine (2023) The pivotal Phase 2 obesity trial of retatrutide, published in the New England Journal of Medicine, enrolled 338 adults with obesity (BMI ≥30) or overweight with weight-related comorbidities
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The mechanistic claim being made is worth stating precisely: in these papers, the brain is not protected by something acting locally in brain tissue
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