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ALA also remarkably decreases the protein level of inflammatory factors including NF-κB, TNF-α, IL-6, IL-1β, and cyclooxygenase-2 (COX2), as well as increases the expression of Nrf2-induced antioxidative enzymes such as SOD1 and glutathione peroxidase (GPx)

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Additionally, selenium plays a role in the regulation of the immune system, such as decreasing inflammation and oxidative stress