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Table 6–5 Nuclear Receptors and Ligands That Induce Drug Metabolism For example, omeprazole, a proton pump inhibitor used to treat gastric and duodenal ulcers ( see Chapter 45 ), is a ligand for the AHR and can induce CYP1A1 and CYP1A2, possibly activating toxins/carcinogens as well as drug-drug interactions in patients receiving agents that are substrates for either of these CYPs

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Inflammatory-response and epithelial-barrier signaling are being observed alongside collagen and structural communication pathways