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Key findings (Saberi, Phytother Res, 2020) [41]: Women given milk thistle extract reported about 3 fewer hot flashes per day compared to baseline after 8 weeks This improvement persisted for 4 weeks after stopping the supplement Women reported a 68% reduction in hot flash severity (from 5.25 to 1.70 points on a 10-point scale) Frequency and severity remained unchanged in the placebo group Women with very severe symptoms were excluded, so it is uncertain whether milk thistle would be beneficial in such cases
