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Metformin’s AMPK-dependent actions also extend to cardiopulmonary I/R models, where it reduces oxidative stress, suppresses inflammatory cytokines (TNF-α, IL-1β), and inhibits NF-κB signaling, collectively preserving tissue integrity (Liu et al., 2024)

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Dermal papilla cells express VEGF during the anagen phase of hair growth, and VEGF plays a critical role in controlling perifollicular angiogenesis [71]