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This was defined as a 1-point to 2-point decline in the Revised ALS Functional Rating Scale (ALSFRS-R) total score over an initial three-month observational period
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Indirect effects The hypoxia-induced acidic microenvironment of tumors can affect drug efficacy 45 , and promote the phenotypic expression of breast cancer stem cells (CSCs) and the acquisition of MDR in breast cancer
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