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Despite this, there have been promising recent reports of the use of a PET tracer, 18F-F0502B, with high selectivity for alpha-synuclein over tau and beta-amyloid, and displaying preferential uptake in non-human primate models of PD over controls 209

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Elevated NAD+ levels activate sirtuins, particularly SIRT1, which are NAD+-dependent deacetylases that regulate numerous metabolic processes including fat oxidation, glucose metabolism, mitochondrial biogenesis, and cellular stress responses