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A plausible scenario for this stimulus-dependent cytoplasmic splicing of I- Gpx4 in hippocampal cells, is that this transcript processing in cellular domains distant from cellular nucleus, as is the case of dendrites, would enhance the antioxidant buffering capacity against the acute generation of lipid peroxides by oxidative insults, which would commit the integrity of membrane unsaturated phospholipids, especially those enriched in DHA
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