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Moreover, excessively high calcium levels in mitochondria induce the activation of calmodulin-dependent protein kinase II delta (CaMKIIδ) and the RIPK3/MLKL cascade, while overexpression of MFN2 significantly inhibits necroptosis [169]

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The role of tetrahydrobiopterin (BH4), an essential enzyme cofactor for tyrosine and dopamine synthesis regulated by inflammatory cytokines, could explain the close interaction between the dopaminergic system and the inflammatory state

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