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52 Monovich and co-workers performed an extensive study assessing the properties of 6-, 7-, and 8-mer MCPs to determine that two factors are highly predictive of oral bioavailability and membrane permeability: (i) the lowest free energy of transition, Δ G * transfer , between aqueous and membrane states and (ii) the lowest number of solvent exposed backbone NH groups in an MCP

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Although TWPs mainly originate from land, their small size and light weight make them easily transport for long distance through air circulation, precipitation, and surface/subsurface runoff, ultimately enter the marine environments ( Figure 1 ) (Evangeliou et al., 2020