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"An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate"

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EZH2 inhibitors Histone methyltransferase EZH2 (enhancer of zeste homolog 2), which is the catalytic subunit of the PRC2 (polycomb repressive complex 2), can alter downstream target gene expression through trimethylation of histone 3 on lysine 27