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When we say HPA axis dysregulation, we’re acknowledging that there are complex interactions and feedback mechanisms involved in someone’s stress response that depend upon communication between the hypothalamus, pituitary gland, and adrenal glands, rather than suggesting that the adrenal glands are solely to blame

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Clinically, solvent drag contributes to the efficacy of simple Na + and carbohydrate-containing oral rehydration solutions that have been used to treat countless individuals with potentially fatal, high-volume diarrhoeal diseases, such as cholera