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Contraindications Do not use Semax if you: Are pregnant or breastfeeding (insufficient safety data) Have uncontrolled hypertension Have severe psychiatric conditions (particularly acute psychosis) Have known allergy to Semax or its components Use with caution if you: Have diabetes (Semax may increase blood glucose—monitor levels) Have anxiety disorders (may worsen anxiety in some individuals) Are taking psychiatric medications (potential interactions) Have a history of seizures Drug interactions Semax affects multiple neurotransmitter systems, creating potential for interactions: SSRIs/SNRIs: Combined serotonergic effects—monitor for symptoms of serotonin syndrome MAOIs: Avoid combination due to catecholamine and serotonin interactions Antipsychotics: May reduce Semax effectiveness or vice versa Other nasal medications with vasoconstrictive effects: Avoid concurrent use For a broader overview of peptide safety, see our peptide safety and risks guide