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Three parameters mainly determine the specific and effective Cre-loxP recombination in vivo : (1) the dose and duration of TAM that determine the activity of the potent metabolites 4-OH-TAM and END, (2) the level of Cre ERT2 expression and (3) the chromatin structure and epigenetic status of the floxed alleles
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Cell Metab (2020) 32(1):15–30
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