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GPx3 can inhibit the activation of NF-κB through the Erk pathway, leading to the suppression of the cell-cycle proteins B1 and G2/M and the inhibition of EMT by downregulating the Erk-NF-κB-SIP1 signaling axis [126,142]

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Male BC patients are usually diagnosed later, with a mean age of 65–70 years, compared to 55–60 years for female BC (Scomersi et al., 2021), with delayed diagnosis often leading to more advanced disease stages and poorer prognoses, partially due to lower awareness and underutilization of screening tools