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In murine models, sleep disruption induced a sizable disturbance in the microbial populations, with alterations in the diversity and richness of the gut microbiome
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This metabolic preference is driven by the MAPK/ERK/p38-c-Myc axis, which upregulates glycolytic enzymes,such as HK2, PFKFB3, LDHA, and lactate production ( B lymphocytes in SLE undergo comprehensive metabolic reprogramming, with heightened glycolysis serving as the central organizer, supported by PPP activation and TCA cycle adaptation