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For most healthy adults, it's clinically insignificant, but people with cardiovascular conditions should discuss topical minoxidil use with a physician

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Rats treated with 0.5mg/kg/day intraperitoneal MOTs-C for 12 weeks were noted to have improved mechanical efficiency of the myocardium during exercise training over the placebo group.7 Data on the impact of exogenous MOTs-C on exercise tolerance in humans is not available, though, studies of endogenous MOTs-C levels have noted an 11.9 fold increase in MOTs-C levels in skeletal muscle in response to exercise, as well as increases in circulating levels of MOTs-C by 1.5 fold during exercise.5 MOTs-C is also of interest for a potential impact on longevity