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Furthermore, CagriSema’s dual mechanism means it could potentially replace multiple medications, simplifying treatment regimens for individuals who are often on numerous medications

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However, despite its important applications, only one TDC structure from Methanococcus jannaschii (PDB code: 3F9T, Mj TDC) has been resolved and deposited in the PDB database, and the key residues responsible for substrate binding and the catalytic mechanism remain unclear